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Fig. 2. Signaling from the stem cell niche regulates Drosophila GSC self-renewal and maintenance. GSCs (yellow) attach to niche cells (blue) through adherens junctions (AJ, grey). The mitotic spindle (green) is oriented orthogonally to the supporting niche cells, ensuring that one stem cell daughter remains within the niche, whereas the other daughter cell is displaced out of the niche and differentiates. (A) Secretion of the Upd ligand from hub cells (blue) activates JAK-STAT signaling in the male GSC. Mitotic spindles are anchored to the GSC cortex by Apc2 (pink), and GSC daughters initiate differentiation as gonialblasts (light green). (B) Secretion of Dpp from cap cells (blue) activates TGF-ß signaling in female GSCs, which represses transcription of the differentiation factor bag of marbles (bam). Mitotic spindles are anchored to the GSC cortex by the spectrosome (orange), and GSC daughters initiate differentiation as cystoblasts (light green).





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