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Fig. 13. Schematic of a muscle cell showing potential localizations/interactions of nesprin-2 isoforms. Isoforms potentially form a network linking the nucleus and organelles to the sarcomere and plasma membrane via the actin cytoskeleton. Continuity of interactions across the NE may occur if SUN domain proteins form a bridge across the nuclear membranes and bind to nesprin-2 isoforms on both the inner and outer faces (not shown).





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