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Fig. 2. Diagrammatic representation, drawn to scale, of the intron/exon splicing events that generate all nesprin-2 isoforms identified to date. Sites of alternate initiation and termination as well as alternatively spliced coding exons along the length of the giant isoform are shown. Coding exons are blue while alternatively spliced coding exons are green and starred. These are not specific to any isoform but utilized in some tissues in a number of isoforms. The 5' and 3' UTRs of each isoform are shown in yellow and red, respectively. Introns are represented by lines, with the majority of introns 1, 2 and 45, omitted because of size constraints.





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