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Fig. 6. In vitro co-immunoprecipitation (IP) assays demonstrating (A) nesprin-2{alpha} and -2ß binding to lamin A and (B) emerin. IP of nesprin-2ß with lamin A and emerin could be demonstrated with both N2 and N3 antibodies (N2 only shown). (C) Binding of nesprin-2{alpha} or -2ß to lamin C could not be demonstrated. (D) Although both nesprin-1 and nesprin-2 bind lamin A, nesprin-2 does not bind to nesprin-1 (D).





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