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Fig. 8. Mislocalization of nesprin-2 isoforms in SW13 cells, and relocalization in SW13/20 cells. Nesprin-2 isoforms recognised by both the N2 (A, upper panel) and CH3 (B, upper panel) antibodies were mislocalized to the ER where they colocalized with emerin in lamin-A-negative SW13 cells. However, in lamin-A-GFP SW13/20 cells nesprin-2 isoforms recognised by these antibodies were correctly re-localized to the NE (A and B, lower panels) with emerin (C). With the N2 antibody there was also some mislocalization of nuclear nesprin-2 isoforms to punctate spots that were more evenly redistributed in lamin-A GFP SW13/20 cells (A).





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