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Fig. 9. Effects of point mutations within the LIM domains on migfilin localization to cell-ECM adhesions. (A-D) Mig-2 localizes to cell-ECM but not cell-cell adhesions. Primary newborn human embryonic keratinocytes were double stained with mouse monoclonal anti-Mig-2 antibody 3A3 (A) and phalloidin (B). HaCat cells that were transiently transfected with the GFP-migfilin(s) vector (C) were stained with the mouse monoclonal anti-Mig-2 antibody (D). (E-L) HaCat cells that were transiently transfected with expression vectors encoding GFP-tagged migfilin mutants (as indicated) were stained with the mouse monoclonal anti-Mig-2 antibody (F, H, J and L). Bar, 8 µm.
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