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Fig. 3. Time course of Ang-2-mediated endothelial-cell-monolayer destabilization in HUVEC/HUASMC co-culture spheroids. Gaps in the endothelial-cell monolayer are first observed after 30 minutes. Individual endothelial cells have detached from the monolayer within 60 minutes of Ang-2 exposure (arrowheads).





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