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Fig. 4. The BM is disorganized in the inflamed ear of a 4-month-old ß4flox/flox; K14-Cre mouse. (A-F) Cryosections of inflamed ear processed for indirect immunofluorescence and visualized by confocal microscopy. Primary antibodies are against proteins that are indicated in the left lower corner of each image and colors are coded according to FITC or Texas Red secondary antibodies. (A,B) Images show that the removal of ß4 is associated with keratinocyte activation as visualized by keratin-6 staining (A) and the deposition of fibronectin into the BM (B). (C-F) Higher magnifications illustrating the presence of blisters when {alpha}6ß4 is absent (D, arrows), the alteration of the BM components collagen IV and Ln-5 in inflamed regions of the skin showing lamination (C,F, arrows) and the deposition of fibronectin into the BM (E, arrow).





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