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First published online February 23, 2005

Journal of Cell Science 118, 504e (2005)
© The Company of Biologists Limited
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In this issue

Ste20 relative gets the Nak of polarity


The shape of individual cells, which contributes to the final form of multicellular organs and tissues, is controlled by polar growth, which is itself regulated by the microtubule and actin cytoskeletons. On p. 1033, Klaus Leonhard and Paul Nurse report that the Ste20-related protein kinase Nak1/Orb3 polarizes the actin cytoskeleton of fission yeast during the cell cycle. The cylindrical cells of fission yeast grow from F-actin-rich tips at opposite ends of the cell. At the onset of mitosis, F-actin relocalizes to the medial ring of the cell, where it regulates cytokinesis. The authors show that inactivation of Nak1/Orb3 in a temperature-sensitive orb3 mutant disrupts the normal cell-cycle-dependent pattern of F-actin localization and produces orb-shaped fission yeast cells that fail to separate after mitosis. They also describe how the localization of Nak1/Orb3 normally changes during the cell cycle and propose that the periodic phosphorylation of Nak1/Orb3 may control its localization, thereby coordinating the reorganization of the actin cytoskeleton and the regulation of cell separation with cell-cycle progression.


Related articles in JCS:

Ste20/GCK kinase Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle
Klaus Leonhard and Paul Nurse
JCS 2005 118: 1033-1044. [Abstract] [Full Text]  




This Article
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