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Fig. 1. Robust and rapid optic nerve regeneration in P3 Bcl-2tg mice. Photomicrograph montages of adjacent longitudinal optic nerve sections and confocal epifluorescence photomicrographs show axonal morphology of wt (A,B) and Bcl-2tg (C-G) mice at 24 (A-D) and 48 hours (E-G) after optic nerve crush. The sections revealed CTB-R labeling (A,C) or were stained with antibodies against NF-M (B,D-G). F and G show higher-magnification views of axon and growth cone morphologies (100x). Asterisks indicates the crush site; arrowheads indicate growth-cone-like structures. Bar, 100 µm (A-C); 40 µm (D,E); 10 µm (F,G).





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