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Fig. 5. Robust optic nerve regeneration in adult Bcl-2tg mice after treatment with astrotoxin. (A-H) Photomicrograph montages of adjacent longitudinal optic nerve sections on day 8 after optic nerve crush in adult wt and Bcl-2tg mice. The asterisk indicates the crush site. Bar, 250 µm. (I,J) Electron micrographs (EM) of optic nerve sections collected at 0.5 mm posterior to the crush from wt (I) and Bcl-2tg (J) mice treated with astrotoxin. Asterisks indicate crush sites; white lines mark GFAP-negative area. Bar, 1 µm. (K) Quantification of regenerating axons from optic nerve sections. Values are mean±s.e.m. (***P<0.001).





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