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Fig. 6. The five N-terminal amino acids of the transmembrane domain of CD98 are required for increased cell adhesion and migration. (A) The different IMCD cell populations transfected with the CD98 constructs indicated were plated on collagen I at the concentrations indicated as described in Fig. 3. The values represent the mean±s.e. of quadruplicate samples/cell population. (B) Migration assays were performed as described in Fig. 3. Bars and errors represent the mean±s.e. of three independent experiments. Differences in cell adhesion and migration between CD98 or CD98 truncations and vector control cells (*) or between CD98-82 and CD98 (#) were significant with P<0.05.





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