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Fig. 7. Inhibitory effects of latrunculin B on Ca2+-dependent Cl– current spikes are mediated by an inhibition of the underlying local Ca2+ signal. Latrunculin B inhibits Ca2+-dependent Cl– current spikes induced by (2,4,5)IP3 in whole-cell patch-clamped pancreatic acinar cells (A). At time points i-v shown in the patch-clamp trace the average Ca2+ signal, denoted by an asterisk and measured within the white box shown in the phase image, was measured (B). The pseudocolour fluorescence ratio image at these times is also shown.





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