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Fig. 10. Proposed model for the link between stress granules and mRNA degradation bodies. Translation block in response to stress or translational repression by factors such as FMRP, mutated eIF2-{alpha} or GFP-CPEB, leads to the storage of mRNAs in stress granules. These granules can either revert if the stress disappears or progressively recruit dcp1 bodies to degrade mRNAs. In contrast, translation inhibitors enabling the release of mRNAs, like puromycin, lead directly to the default mRNA degradation pathway which takes place within the dcp1 bodies. However, translation inhibitors that trap arrested mRNAs on polysomes, such as cycloheximide (CHX), prevent them from joining the dcp1 bodies.





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