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Fig. 8. Schematic representation of the p53BS of three p53-target genes showing the pentamer orientation in each decamer. (a) Head-to-head (HH) for the canonical 20-bp p53-binding site, as in the Waf1/p21 promoter; (b) in tandem, head-to-tail (HT), as in the MDR-1 promoter; and (c) tail-to-tail (TT) as in the BTG2TIS21/PC3 promoter. Pu, purine; Py, pyrimidine.





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