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Fig. 1. Construction of a three-dimensional model of the structure of the LpR ectodomain from the third cysteine-rich repeat to the EGF-C module (black). The LpR structure is superimposed onto the X-ray crystal structure of the LDLR ectodomain from the second cysteine-rich repeat to the EGF-C module at pH 5.3 (grey); this reveals that His562 in LDLR corresponds to Asn643 in LpR. Enlargement of the frame shows the side chains of His190, His562 and His586 of LDLR (grey) in the interface between cysteine-rich repeats 4 and 5 of the ligand-binding domain and the ß-propeller of the EGF domain in LDLR, and the Asn643 residue in LpR (black). CR, cysteine-rich repeats.





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