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Fig. 8. Quantification of constitutive RRE (black) by counting the relative numbers of transfectants in which the receptor had perceptibly converged in the ERC after a short pulse of fluorescently labelled ligand. RRE after prolonged lipoprotein incubation (grey) was determined after a similar pulse preceded by a 90-minute preincubation of unlabelled ligand. ldlA(LDLR), ldlA(LDLR_1-292LpR_343-850), ldlA(LDLR_H562N) and ldlA(LDLR_H562Y) transfectants were incubated with LDL, and CHO(LpR), CHO(LpR_1-790LDLR_791-839) and ldlA(LpR_1-342LDLR_293-839) transfectants with Lp. Error bars show s.d. of each duplicate experiment (s.d. LpR_1-790LDLR_791-839 < 0.1%; LDLR ${Delta}$ EGF, single experiment). The total number of cells counted for each data set is indicated at the bottom of each bar.

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