spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 2. Overview of the steps involved in the production of collagen fibrils by fibroblasts. Procollagen chains are synthesized in the endoplasmic reticulum (ER), are brought together by interactions between the C-propeptides and fold to form a rod-like triple-helical domain flanked by globular N- and C-propeptides. The large number of post-translational modifications that occur in the ER are not depicted. Removal of the N- and C-propeptides from fully folded procollagen only occurs after transport of procollagen across the Golgi stacks and results in collagen molecules that are then able to assemble into fibrils. Covalent crosslinks occur within and between triple-helical collagen molecules in fibrils.





Right arrow Return to article