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Fig. 11. Effects of modulating phototransduction on retinal degeneration in rdgA³. (A) Time course of retinal degeneration in rdgA³ compared with wild-type (Oregon-R ROR) flies. Flies were grown in a normal laboratory incubator and experienced brief pulses of light when the incubator doors were opened. ROR flies show no degeneration under these conditions. On eclosion, rdgA³ flies show wild-type rhabdomere structure by optical neutralization but then progressively degenerate over 72 hours. (B) Rates of degeneration compared in rdgA³ flies grown in normal incubator (NI), constant darkness in black photographic bags (24h D) and in a illuminated cooled incubator on light/dark cycles (12h L/12h D). (C) Rates of degeneration of rdgA³ compared with rdgA³;Gq¹. In this experiment, flies were grown in the normal incubator. (D) Rates of degeneration in ROR, rdgA³ and norpA^P24,rdgA³. There is virtually complete suppression of degeneration in norpA^P24,rdgA³. In this experiment, flies were grown in a normal incubator.

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