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Fig. 9. Effect of specifically disrupting the TRP-INAD interaction on rdgA¹. (A) TEM of rdgA¹;InaD^P215 double mutants showing no rescue of degeneration. (B) Rescue of rdgA¹ by trp^CM assayed by optical neutralization. When grown at 29°C, the restrictive temperature for trp^CM, rdgA¹;trp^CM show rescue of degeneration compared with that at the permissive temperature of 20°C. The images of rhabdomeres R1-R7 can be seen. Expression of TRP¹²⁷² channels in rdgA¹;trp^CM mutants at 29°C results in severe retinal degeneration.

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