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Fig. 9. Model for the role of ninein in microtubule organization by the centrosome. Microtubules are nucleated by the {gamma}-TuRC, which is enriched at the centrosome. The newly nucleated microtubules could have different behaviours. (1) Microtubules are nucleated far from the subdistal appendages. They are transiently anchored by the {gamma}-TuRC or released from the centrosome. (2) A proportion of the {gamma}-TuRC is docked at the mother centriole by ninein. Microtubules nucleated by this {gamma}-TuRC near or on the subdistal appendages would be quickly captured by the anchoring complex.





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