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Fig. 2. STAT-1 is required for activation of the ATM-Chk2-Cdc25A and ATM-NBS1 pathways. (A) 2fTGH, U3A and U3A-ST1 cells were exposed to 0, 2 or 10 Gy {gamma}-IR. Cells were harvested after 2 hours and extracts were incubated with relevant antibodies against the proteins indicated on the western blot. (B) 2fTGH, U3A and U3A-ST1 cells were exposed to {gamma}-IR (2 Gy), fixed after 2 hours and immunofluorescence analysis with antibody against phosphorylated Chk2-T68 was carried out. (C) U3A-ST1 and U3A cells were exposed to 2 or 10 Gy {gamma}-IR; cells were harvested 2 hours later and extracts immunoblotted with antibodies against the proteins indicated. (D) U3A-ST1 and U3A cells were exposed to {gamma}-IR (2 Gy), fixed after 2 hours and immunofluorescence analysis was carried out with antibodies against the proteins indicated. The dimensions of the field of view are 40 mM x40 mM.





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