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Fig. 9. The route of trafficking of Syt IX. A cartoon illustrating the proposed route of trafficking of Syt IX, from the TGN to the plasma membrane (PM), early endosomes (EE) and the ERC. According to this model, Syt IX travels from the TGN to the plasma membrane by the constitutive secretory pathway. At the plasma membrane, Syt IX is phosphorylated by a classical PKC resulting in its internalization and delivery to the ERC. The rate-limiting factor in this step is the phosphorylation by PKC, then the phosphorylated protein is rapidly internalized and delivered to the ERC, where it undergoes dephosphorylation.





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