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Fig. 5. Wound healing and cell migration. (A-J,M,N) Two 3 mm punch biopsies were made on the back of each control (Ct) or KO mouse as indicated. Wounds 2 days (A,E) or 4 days (B,F) after wounding. (C,G) Hematoxylin eosin staining of wound sections after 2 days. (D,H) Higher magnification details of C and G. (I,M) ß1 integrin (green) and involucrine (red) staining on wound-healing fronts. J,N) Representative BrdU staining on wound-healing fronts (green). Green cornified layer in M is nonspecific staining. Nuclei were stained with DAPI (DNA either red or blue). (K) Percent of BrdU incorporation in wound-healing fronts after 2 or 4 days (D). (L,P) Representative tracks (16) of elongated-moving keratinocytes (without mitomycine C) from control mouse (L, green) or KO epidermis (P, red). (O) Length of tracks followed by control (Ct) or KO keratinocytes without or after treatment with mitomycine C (mitoC). A dash (–) locates the mean, and bars the s.e.m. (20 cells). Bar, 40 µm in C,D,G,H, 20 µm in I,J,M,N. Dotted line for basal membrane.





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