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Fig. 7. Colocalization of chromosome 9 homologues in wild-type and DNA repair-deficient fibroblasts. Percentage of cells with one hybridization signal for chromosome 9p12-13 band-specific probe observed in wild-type human fibroblasts (VH-25) and fibroblast cell lines derived from XPA and XPF patients. Confluent cells were treated for 1 hour with 4 µM MMC and fixed directly afterwards. Analysis was preformed manually in 500 cells per experiment. The average percentage of at least three experiments is presented together with the standard deviation of the mean values. A significant increase (P<0.05, Student's t-test) in the number of cells with one hybridization signal was observed for wild-type and XPA fibroblasts. In XPF cells there was no significant change; the data were taken from cells of two different XPF patients.





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