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Fig. 8. Chromatid interchanges and breaks induced by MMC in wild-type and XPF lymphoblastoid cells. (A) Genomic frequencies for chromatid interchanges as observed in wild-type and XPF lymphoblastoid cells. Exponentially growing cells were treated with 4 µM MMC for 1 hour at different recovery times. Data from at least two experiments were analyzed. The difference between wild-type and XPF cells is significant at 28 hour and 40 hour time points (P<0.05, Student t-test). (B) Frequencies of chromatid exchanges and breaks observed for chromosome 9 after a recovery of 28 hours. A significant difference was observed only for exchanges (P<0.01, Wilson's method).





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