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First published online April 5, 2005

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Septins keep yeast tidy

Septins are conserved filament-forming proteins that assemble into cortical cytoskeletal structures in animal and fungal cells. In budding yeast, in preparation for bud formation, the GTPase Cdc42p organizes septins into a ring that later forms a collar at the mother-bud neck. Daniel Lew and colleagues have investigated the interplay between septin organization, the cell cycle and cell shape by dissecting the phenotype of yeast cdc42^V36T,K94E cells, in which an aberrant cell shape correlates with the development of ectopic septin caps and rings within the bud (see p. 1617). Their analysis indicates that this phenotype results from the interaction of several parallel pathways that are affected by the loss of septin integrity, including pathways affecting cell-wall deposition, cell-cycle control and cell polarity. It also reveals that the septin collar in wild-type cells helps to shape the nascent bud and inhibits the assembly of ectopic septin rings. Finally, the authors devise an assay for subtle septin defects and identify many additional genes that control septin organization.

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Related articles in JCS:

Interplay between septin organization, cell cycle and cell shape in yeast

Amy S. Gladfelter, Lukasz Kozubowski, Trevin R. Zyla, and Daniel J. Lew
JCS 2005 118: 1617-1628. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?