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Fig. 4. Cell-cycle distribution of cells lacking RB proteins in response to DNA damage. Primary MEFs were treated with etoposide or adriamycin, and cell-cycle distributions were determined using FACS. (A) Effect of etoposide on wild-type (WT) and p130/p107/p105RB-null (triple-knockout, TKO) MEFs. Histograms of DNA content are shown. (B and C) Effect of etoposide and adriamycin on G2 arrest. The percentage of cells with a 4N content of DNA in treated samples is shown relative to the percentage in untreated wild-type or TKO MEFs. In (C), the cells were exposed to adriamycin for 72 hours. Results from two independent experiments are shown.





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