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Fig. 2. Bcl6–/– macrophages display altered focal complex and F-actin structures. Bcl6+/+ (A,C,E,G,I,K) and Bcl6–/– BMM (B,D,F,H,J,L) were plated on fibronectin-coated coverslips, grown to subconfluence in the presence of CSF1, then starved of CSF1 for 24 hours prior to re-stimulation for 20 minutes. Immunofluorescence samples (A-H) were stained for Y118 paxillin (C,D; green in merged fields G,H) and F-actin (E,F; red in merged fields). Arrows indicate dense collections of phospho-paxillin-rich point contacts, closed arrowheads indicate focal complexes that subtend F-actin bundles, and open arrowheads indicate circumferential focal complexes with overlying F-actin belts. Inserts in H highlight the focal complexes and F-actin structures. (I,J) Representative cytoskeletal replicas. (K,L) Enlarged regions framed in I and J. Bar, 10 µm (A-H); 500 nm (I,J).





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