spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 8. Surface CSF1R expression and colocalization with RhoGAP is reduced in Bcl6–/– macrophages. RhoGAP (C and D) colocalizes with the CSF1R (E and F) at the plasma membrane. Localization of RhoGAP and the CSF1R to the plasma membrane both appear reduced in Bcl6–/– BMM. Up to 20-25% of BMM may be binucleate. Arrowheads highlight plasma membrane ruffles. (G) CSF1R western blot analysis showed reduced expression of the mature 165 kDa isoform in Bcl6–/– BMM and the presence of a potential proteolytic cleavage product with molecular mass of ~100 kDa. Lower panel, GAPDH loading control. (H) FACS analysis of surface CSF1R expression in vector-transduced Bcl6+/+ and Bcl6–/– BMM, and BCL6-reconstituted Bcl6–/– BMM. Bar, 10 µm.





Right arrow Return to article