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Fig. 9. Overexpression of the CSF1R corrects the phenotype of Bcl6^–/– BMM cultured in CSF1. (A) FACS analysis of surface CSF1R expression in vector-transduced Bcl6^+/+ and Bcl6^–/– BMM, and CSF1R-transduced Bcl6^–/– BMM. (B) Polarization indices of vector-transduced Bcl6^+/+ and Bcl6^–/– BMM, and GFP-expressing CSF1R-transduced Bcl6^–/– BMM (error bars, s.e.m.; *P<0.02 significantly different from index in Bcl6^+/+ BMM). (C-I) Bcl6^–/– BMM overexpressing the CSF1R, as judged by high GFP levels (C, cell in the lower left corner), showed reversion of adhesion structures from peripheral focal complexes typical of Bcl6^–/– BMM (E) to widespread ventral surface point contacts (F, cell in the lower left corner), similar to those seen in Bcl6^+/+ BMM (D). Corresponding phase-contrast images are also shown (G-I). Bar, 10 µm.

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