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Fig. 3. Colons from 2-week (wk), 4-wk and 6-month (mo)-old K8+/+ and K8–/– mice analyzed by histology and immunohistochemistry. (A) Hematoxylin and Eosin staining of colons from 2-wk and 4-wk-old K8–/– mice show increased areas of inflammation (d,f, arrows). Frozen colon sections from 2-wk-old K8+/+ and K8–/– mice were stained with anti-CD4 FITC (b,e). K8–/– colon LP shows increased CD4+ cells (e, arrows). L, lumen; M, muscle layer. Scale bar: 10 µm (a,c,d,f); 30 µm (b,e). (B) Frozen sections from 2-wk and 6-month-old K8+/+ and K8–/– colons were stained with anti-EPCAM (an epithelial cell marker, red), anti-I-A/I-E (MHC class II antigens, green), and a nucleus-staining dye (Toto-3, blue). Note the overexpression of MHC class II antigens (arrows) in colonocytes of K8–/– mice. Scale bar: 10 µm.





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