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Fig. 5. Expression of {alpha}4ß7 and endothelial markers by K8+/+ and K8–/– colons. (A) Frozen sections from 3-month-old K8+/+ (a) and K8–/– (b) colons were stained with anti-{alpha}4ß7. Sections from 6-month-old K8+/+ (c,e) and K8–/– (d,f) colons were stained with anti-MAdCAM-1. Increased {alpha}4ß7+ cells (b) and MAdCAM-1+ venules (d,f, arrows) were seen in K8–/– colons. L, lumen; M, muscle layer. Scale bars: (a-d) 50 µm; (e,f) 30 µm. (B) Colons from K8+/+ (a,c) and K8–/– (b,d) mice were double-stained for the endothelial markers anti-PECAM/CD31 (green) and the vascular adhesion molecule PNAd (red). Merged images are shown in e and f. Inserts show a magnified view of a positive double-stained venule. Note the aberrant expression of PNAd in K8-null colon (compare c and d). Arrows in f indicate areas of co-localization. Scale bar: 50 µm.





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