QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online December 21, 2005

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Nuclear pores: tight squeeze for viral DNA

Before eukaryotic DNA viruses can replicate, they must enter the host nucleus through nuclear pore complexes (NPCs) in the nuclear envelope. Human herpes simplex virus type 1 (HSV-1), like other large viruses, docks onto NPCs before releasing its genome from the viral capsid, but how the bulky genome gets through NPCs is a mystery. Victor Shahin and colleagues now report that the HSV-1 genome translocates through the NPCs of Xenopus oocytes as a condensed, rod-like structure (see p. 23). By using atomic force microscopy, the authors show that, in addition to capsids, subviral structures 30-40 nm wide and 130-160 nm long stick to the cytoplasmic side of NPCs in Xenopus oocytes. These subviral structures, which probably consist mainly of the viral genome, are the only viral structures to be translocated through the central channels of the NPCs, which widen considerably to allow their passage.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

The genome of HSV-1 translocates through the nuclear pore as a condensed rod-like structure

Victor Shahin, Wali Hafezi, Hans Oberleithner, Yvonne Ludwig, Barbara Windoffer, Hermann Schillers, and Joachim E. Kühn
JCS 2006 119: 23-30. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?