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Fig. 3. Ca²⁺ waves in PERK^-/- pancreatic acinar cells. PERK^-/- pancreatic acinar cells were stimulated with the indicated concentrations of carbachol. (A,B) Selective images of cells stimulated with 5 µM (A) or 100 µM carbachol (B). (C) Changes in [Ca²⁺]_i at the apical (green regions of interest and traces) and basal poles (red regions of interest and traces). (D) The rate of the Ca²⁺ waves recorded in cells stimulated with 0.1 and 1 mM carbachol. The results are the mean ± s.e.m. of 5/11 cells stimulated with 100 µM carbachol that showed a Ca²⁺ wave and of 8/8 cells stimulated with 1 mM carbachol (Carb). All results in A and B were obtained in the absence of Ca²⁺_o and similar results were obtained in the presence of 1 mM Ca²⁺_o. The averages are from cells stimulated in the presence or absence of Ca²⁺_o.

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