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Fig. 5. Ca²⁺-induced Ca²⁺ release in WT and PERK^-/- parotid acini. WT (A,C) and PERK^-/- parotid acini (B,D) were incubated in Ca²⁺-free medium and either stimulated with 1 mM carbachol (A,B) or treated with 10 µM CPA for 2 minutes. Then the acini were alternately exposed to medium containing 7.5 or 0 mM Ca²⁺ to induce CICR. (E) The averaged peak increases in [Ca²⁺]_i. (F) Ratios between the first and second peaks (carbachol stimulation) and first and third peak (CPA treatment) evoked by addition of 7.5 mM Ca²⁺ to WT (dotted lines) and PERK^-/- cells (dashed lines) in A-D. Summaries are from at least four experiments each and are given as the mean ± s.e.m.

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