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Fig. 7. Ca_v1.2 and caffeine-induced Ca²⁺ release in WT and PERK^-/- urinary bladder smooth muscle cells. (A) WT (black traces and column) and PERK^-/- (gray traces and column) cells were used to measure Ca_v1.2 current. (B) The voltage dependence of Ca_v1.2 in WT ( ${blacksquare}$ ) and PERK^-/- cells ( ${circ}$ ). WT (C) and PERK^-/- UBSM strips (D) were exposed to caffeine concentrations between 5-40 mM and then depolarized with 80 mM K⁺ to measure the activity of the RyRs in the UBSM. (E) The average response of four strips from two WT and two PERK^-/- mice given as the mean ± s.e.m.

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