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Fig. 6. Full-length Myo10 localizes to sites of cell-cell contact. (A) In undifferentiated CAD cells, GFP-Myo10 (green) is present at the tips of short filopodia-like structures at sites of cell-cell contact. The panels on the right shows high-magnification views of the inset. (B) GFP-Myo10 is also present at the tips of filopodia at sites of cell-cell contact in differentiated CAD cells. The panels on the right show high-magnification views of the inset and illustrate that Myo10 is present at the tips of filopodia that are contacting neurites. Cells were double-labeled for F-actin by staining with rhodamine-phalloidin (red). Although under the exposure settings used here some filopodia appear only faintly labeled for F-actin relative to the much thicker neurites and cell bodies, longer exposures indicate that all of the filopodia contain F-actin.
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