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Figure 8


Fig. 8. A model showing the involvement of FAK and Src in UNC5-DCC signaling. FAK interacts via its CTD with the P3 domain of DCC. Src interacts via its SH3 domain with the P1400XXP motif in DCC and via its SH2 domain with phosphorylated UNC5 or FAK. FAK and Src phosphorylate Y1420 in DCC and multiple tyrosine sites in UNC5. Note that molecules are not drawn to scale. CTD, C-terminal domain; DB, DCC-binding motif; DD, death domain; FN, fibronectin type III domain; IG, immunoglobulin domain; NTD, N-terminal domain of FAK; P1, P2 and P3, three conserved domains; TSP, thrombospondin domain; ZU-5, ZO-1/UNC5 domain. The numbers 449/454 and 649/667 indicate sites in UNC5 phosphorylated by Src.





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