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Fig. 1. Principle of single-molecule force spectroscopy measurements in living cells. (A) Schematic of the molecular force probe (MFP) used here to probe cadherin-mediated cell-cell interactions at the single-molecule level. (B) Phase-contrast microscopy of cadherin-expressing CHO cells deposited on a cantilever. (C) Phase-contrast microscopy of adherent CHO cells attached to the end of a cantilever. Scale bars, 15 µm (B); 10 µm (C).





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