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Fig. 6. Single-bond analysis of cadherin-mediated cell-cell adhesion. (A) Mean rupture force of a single bond as a function of loading rate. Curve fitting with Bell's model allows for the computation of the unstressed dissociation rate, k0off and the reactive compliance, xß, of a bond. (B) Schematic of the intermolecular potential of interaction between E-cadherin pairs and N-cadherin pairs on apposing cells. This energy potential is qualitatively based on data shown in A. Blue represents the inner barrier potential at high loading rates; green represents the outer barrier potential at low loading rates for the dissociation of a single E-cadherin/E-cadherin bond between cells; red represents the single barrier potential to be overcome for the dissociation of a single N-cadherin-N-cadherin bond. The width of each potential well is taken as the reactive compliance.





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