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First published online May 10, 2006

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Actin' roles for glucose in insulin secretion

One essential role of the actin cytoskeleton is to regulate vesicle exocytosis. In pancreatic ß-cells, actin filaments limit the access of insulin granules to the plasma membrane but may also facilitate regulated hormone secretion. To untangle the relationship between insulin secretion and the actin cytoskeleton, Alejandra Tomas and colleagues have studied two sublines of the mouse pancreatic ß-cell line MIN6: the B1 subline responds to glucose by secreting insulin, the C3 subline does not. On p. 2156, the authors show that, whereas C3 cells have a rigid cytoskeleton that does not remodel after glucose stimulation, B1 cells have shorter actin filaments, which depolymerize readily in response to glucose. This depolymerization, they report, depends on the Ca²⁺-dependent actin-remodelling protein gelsolin. Furthermore, the authors find that actin polymerization affects the localization of components of the MAP kinase signalling cascade, which regulates ß-cell insulin secretion in response to glucose. Thus, they conclude, actin remodelling potentiates ß-cell insulin secretion both by removing a physical barrier to the process and by regulating MAP kinase signalling.

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Related articles in JCS:

Regulation of pancreatic ß-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway

Alejandra Tomas, Barbara Yermen, Le Min, Jeffrey E. Pessin, and Philippe A. Halban
JCS 2006 119: 2156-2167. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?