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Figure 1


Fig. 1. Nuclear tau localizes at the border of the nucleolus. Colocalization of endogenous tau with heterochromatin was analyzed by immunofluorescent technique and confocal microscopy in human skin fibroblasts and HeLa cells. Each row represents a single optical section of the same nucleus. Left panels (A,D) correspond to diMeH3K9 distribution revealed with rabbit anti-diMeH3K9. Middle panels (B,E) show subnuclear tau distribution detected with the Tau-1 monoclonal antibody. Merged images of tau with diMeH3K9 are shown on right panels for human fibroblasts (C) and HeLa cells (F) with double-labeled pixels displayed in white. (C',F') Enlarged views of C and F showing the overlap between tau and diMeH3K9 at the nucleolus in white. Scale bar, 5 µm.





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