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Figure 3


Fig. 3. Tau partially colocalizes with pericentromeric {alpha}-satellite DNA. Colocalization of endogenous tau with pericentromeric {alpha}-satellite DNA was studied by immuno-FISH and confocal microscopy in human skin fibroblasts, human lymphoblasts and HeLa cells. Each row represents a single optical section of the same nucleus. Left panels (A,D,G) correspond to subnuclear tau distribution detected with the Tau-1 monoclonal antibody. Middle panels (B,E,H) show {alpha}-satellite DNA repeats distribution revealed by FISH using fluoRED labeled {alpha}-satellite p82H plasmid as a probe. Merged images of tau with pericentromeric {alpha}-satellite DNA are shown on right panels for human skin fibroblasts (C), human lymphoblasts (F) and HeLa cells (I) with double-labeled pixels displayed in white. C',F',I' are enlarged views of C,F,I respectively. Bars, 5 µm.





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