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Figure 1


Fig. 1. Interference of the duration of CCR evoked by 40 mM KCl. (a) Baclofen (100 µM) causes a 20% inhibition of CCR (P<0.01) but its effect is abolished after long exposures (60 minutes). (b) Baclofen-induced downregulation of GABAB receptors is counteracted by sucrose (150 mM) and filipin (0.1 µg/ml); P<0.01 compared with baclofen adapted cells. (c) Effect on CCR by 150 mM sucrose, cytosol acidification (pH 5), 0.1 µg/ml filipin and 50 µM P4 peptide. (d) The inhibitory effect of baclofen is enhanced when cells are treated with 150 mM sucrose, 10 mM acetic acid (pH 5.0), 0.1 µg/ml filipin and 50 µM P4 peptide; P<0.01 compared with baclofen non-adapted cells. Tests were carried out on 15 cells and were repeated on four different occasions over several weeks.





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