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Figure 10


Fig. 10. Schematic model of mechanism of mLgl-mediated disassembly of apical domain by suppressing PAR-3-aPKC-PAR-6 complex activity. mLgl suppresses the activity of PAR-3-aPKC-PAR-6 complex by the competitive interaction of aPKC-PAR-6 with PAR-3 and Cdc42. This leads to the disassembly of the apical membrane domain by internalization of apical proteins and orientation of apical membrane polarity. mLgl seems to also be involved in the regulation of tight junction and adherens junction disassembly.





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