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Figure 9


Fig. 9. Loss of megalin/LRP2 and Dab2 abolishes Rab4-positive endosomes within the pronephric duct. Confocal fluorescence microscopy on transversal sections through the pronephic ducts of 72 hpf wild-type (A,E,I), megalin/lrp2 morphants (B,C,F,G,K,L), or dab2 morphants (D,H,M) injected with 70kDa-FD (A-D,I-M) and immunostained for the early endosomal marker Rab4 (E-M). megalin/lrp2 morphants (K,L) and dab2 morphants (M) are devoid of tubular Rab4-positive endosomes and lack uptake of 70kDa-FD compared with controls (I). Bar, 20 µm.





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