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Figure 7


Fig. 7. Effect of JP-45 overexpression on Cav1.1 charge movement. (A,B) Maximum charge-movement versus fluorescence for C2C12 cells transfected with either pFP-N3-DsRed2 JP-45 (A) or pFP-N3/DsRed2 alone as control (B). The lines in A and B represent the linear regression including all data points. (C,D) Charge-movement versus membrane-voltage (Vm) for pFP-N3-DsRed2-JP-45 (C) or pFP-N3-DsRed2 plasmid (D) transfected cells fitted to a Boltzmann equation (see text). The best fitting parameters are included in Table 1. (E) Charge-movement versus Vm for the five highest and lowest Qmax values (E) from JP-45 transfected cells (C).





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