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Figure 2


Fig. 2. Effect of actin depolymerisation on the secretory response to glucose in B1 and C3 cells. (A) Latrunculin B-dependent depolymerisation of F-actin in B1 and C3 cells. Bar, 20 µm. (B) Stimulatory effect of actin depolymerisation by 10 µM latrunculin B on glucose-dependent insulin secretion in B1 and C3 cells. Left panels: basal (0 mM glucose for 1 hour) and stimulated (20 mM glucose for 1 hour) insulin secretion as a percentage of cell content; rights panels: fold-stimulation (*P<10-4). (C) Time-course of insulin secretion (20 mM glucose) by B1 and C3 cells with or without 10 µM latrunculin B. (D) Insulin content in B1 and C3 sublines with or without 10 µM latrunculin B treatment. Data in all cases are mean ± s.e.m. of three independent experiments.





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