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First published online May 24, 2006

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MORNing parasite break

Toxoplasma gondii, like other Apicomplexan parasites, divides by internal budding: two daughter cells form as buds within the mother cell on a cytoskeletal scaffold, acquire a set of organelles and then emerge. How the cytoskeleton and various endomembranes interact during this process is poorly understood. Now, Marc-Jan Gubbels, Boris Striepen and co-authors report that the MORN-repeat protein MORN1 is a dynamic component of the division apparatus that could play a role (see p. 2236).

MORN (for membrane occupation and recognition nexus) motifs are found in proteins that help organize membranous and cytoskeletal structures. The authors show that, in dividing T. gondii, MORN1 localizes to the centrocone, which organizes the mitotic spindle, and to a ring structure at both ends of the barrel-shaped inner membrane complex (IMC), which delineates the forming daughters. Strikingly, the posterior ring moves along the IMC during mitosis and division and contracts during the final stage of budding. The authors suggest that MORN1 links specific membrane regions of T. gondii to its cytoskeleton during the division process and that microtubular growth moves the MORN1-associated ring.

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Related articles in JCS:

A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus

Marc-Jan Gubbels, Shipra Vaishnava, Nico Boot, Jean-François Dubremetz, and Boris Striepen
JCS 2006 119: 2236-2245. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?